Publications by authors named "H Yucel"
Background/objectives: In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate the effectiveness and safety of regorafenib as a third-line treatment for patients with recurrent glioblastoma who progressed while taking bevacizumab-based therapy.
Methods: This retrospective, multicenter study in Turkey included 65 patients treated between 2021 and 2023 across 19 oncology centers.
Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more effective than ET alone and is safe in elderly patients as well as young patients. Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials.
View Article and Find Full Text PDFA health risk assessment of toxic metals and aflatoxin contamination in homemade and industrial noodles.
Environ Monit Assess
December 2024
Environmental pollution is a problem that affects food safety throughout the world. In this study, a health risk assessment of possible toxic metal and aflatoxin contamination in homemade and industrial noodles produced in Türkiye was carried out. Samples were taken from 67 kinds of homemade and five kinds of industrial noodles from different cities.
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- This research explores the use of trachydacitic, a natural material, as aggregate in concrete for rigid pavements, focusing on two curing methods: standard water curing for 28 days and a combined method involving both water and dry oven curing.
- Four types of concrete mixtures were tested, examining mechanical, durability, and surface abrasion properties under different conditions, with significant findings related to compressive and flexural strengths.
- Results indicated that the combined curing method enhanced strength and durability against freeze-thaw cycles while slightly decreasing resistance to abrasion; trachydacitic aggregate in powdered form showed promise for high-strength concrete applications in road construction.
: Lymphedema is a progressive, chronic condition. Traumatic damage to the lymphatics, removal of lymph nodes, and/or radiation are the major causes of fibrosis and a subsequent pathological cascade. Macrophages play a crucial role in wound healing, with M1 macrophages known for their pro-inflammatory effects and M2 macrophages recognized for their anti-inflammatory effects, including improved angiogenesis, lymph angiogenesis, and tissue healing.
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