Publications by authors named "H Yersiz"
The history of intestinal transplantation can be traced back to the turn of the twentieth century. Although advancements have been made, the intestine still presents a greater challenge to transplantation than does that of other solid organs, experiencing higher rates of graft rejection and lower long-term survival. Increasingly, intestinal re-transplantation (re-ITx) is seen as a viable option and is now the fourth most common indication for ITx.
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- This study analyzed liver retransplantation (ReLT) data over a 35-year period at a single center, revealing that up to 40% of liver transplant recipients experience graft failure.
- A total of 654 ReLT procedures were performed, with significant differences noted between pre- and post-model for end-stage liver disease (MELD) eras in terms of patient age, comorbidities, and causes for retransplantation.
- Findings indicate that despite the challenges faced by post-MELD ReLT patients, survival rates have improved compared to pre-MELD patients, highlighting the effectiveness of careful patient selection in liver retransplantation.
Article Synopsis
- This study compares two methods of preserving donor livers for transplantation: traditional static cold storage (SCS) and normothermic machine perfusion (NMP) which keeps the organs at body temperature.
- The research involved 383 donor livers from various US transplant centers, and while there was no significant difference in early allograft dysfunction rates overall, NMP showed better outcomes for higher-risk donors, particularly in cases of organ donation after circulatory death.
- The conclusion suggests that while NMP may not lower early liver injury rates universally, it is safe and potentially more beneficial for marginal donor livers.
Liver transplantation (LT) for cholangiocarcinoma (CCA) remains limited to a small number of centers. Although the role of neoadjuvant therapy (NAT) has been explored over time, an in-depth analysis of NAT strategies remains limited. Furthermore, controversy exists regarding acceptable tumor size during patient selection for LT.
View Article and Find Full Text PDFBackground & Aims: Early allograft dysfunction (EAD) following liver transplantation (LT) negatively impacts graft and patient outcomes. Previously we reported that the liver graft assessment following transplantation (L-GrAFT) risk score was superior to binary EAD or the model for early allograft function (MEAF) score for estimating 3-month graft failure-free survival in a single-center derivation cohort. Herein, we sought to externally validate L-GrAFT, and compare its prognostic performance to EAD and MEAF.
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