Publications by authors named "H Yatsuhashi"
Introduction: Hand-foot-skin reaction (HFSR) is the most common side effect of multi-tyrosine kinase inhibitor therapy for unresectable hepatocellular carcinoma (uHCC). Sarcopenia has been reported to be a poor prognostic factor for HCC. Here, we performed a randomized controlled trial (RCT) of the efficacy of a β-hydroxy-β-methyl butyrate/l-arginine/l-glutamine (HMB/Arg/Gln) beverage and locomotion training as supportive care in the treatment of uHCC with lenvatinib.
View Article and Find Full Text PDFAim: The incidence of and factors involved in gastroesophageal varix-related events in hepatitis C virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear.
Methods: We conducted a multicenter study using prospective data from 478 hepatitis C virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria.
Article Synopsis
- Adult-onset Still's disease (AOSD) may involve autoinflammation and cytokine imbalance, with the study focusing on the relationship between galectin-3 (Gal-3), a specific protein, and multiple cytokines in Japanese AOSD patients.
- The study included 44 AOSD patients, alongside controls with rheumatoid arthritis and healthy individuals, measuring serum levels of Gal-3, M2BPGi, and 69 cytokines to identify patterns and correlations.
- Results revealed significantly elevated levels of Gal-3 and M2BPGi in AOSD patients, with Gal-3 linked to disease activity and various inflammatory cytokines, and immunosuppressive treatment effectively lowering the levels of both
Article Synopsis
- Previous studies have found both shared and population-specific genetic factors contributing to primary biliary cholangitis (PBC), with more than 20 novel susceptibility loci identified in a recent meta-analysis across different populations.
- A new genome-wide association study (GWAS) focused on the Japanese population identified the gene PTPN2 as a novel susceptibility gene for PBC, linking a specific variant (rs8098858) to the disease.
- The risk allele (rs2292758) is shown to disrupt PTPN2 expression, leading to an impaired negative feedback mechanism in immune signaling, suggesting that targeting PTPN2 could be a promising approach for PBC treatment.
Background: The relationship between liver fibrosis and inflammation and Mac-2-binding protein glycosylation isomer (M2BPGi) in patients with chronic liver disease (CLD) other than hepatitis C remains uncertain, owing to the limitations of qualitative methods. Here, we evaluated the influence of liver fibrosis and inflammation on quantitative M2BPGi (M2BPGi-Qt) in CLD, considering each etiology.
Methods: We recruited 1373 patients with CLD.