Publications by authors named "H Yamamori"
Article Synopsis
- - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
- - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
- - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
Article Synopsis
- Aberrant salience processing is a potential mechanism that might explain psychiatric symptoms in schizophrenia, as seen in abnormal gaze patterns when individuals view images.
- A study involving 1012 participants compared gaze behaviors, revealing that individuals with schizophrenia had gaze trajectories influenced more by visual salience than healthy individuals, particularly in orientation salience.
- The research also indicated that abnormal salience processing varies across different psychiatric disorders, with schizophrenia showing the strongest effects, followed by bipolar disorder, major depressive disorder, and autism spectrum disorder, linking salience abnormalities to the severity of psychotic symptoms.
CATH (https://www.cathdb.info) classifies domain structures from experimental protein structures in the PDB and predicted structures in the AlphaFold Database (AFDB).
View Article and Find Full Text PDFAbnormalities in visual exploration affect the daily lives of patients with schizophrenia. For example, scanpath length during free-viewing is shorter in schizophrenia. However, its origin and its relevance to symptoms are unknown.
View Article and Find Full Text PDFEstablishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study and is defined by clusters of brain regions with reduced volume in schizophrenia patients compared to healthy individuals. This signature was proven to be effective at differentiating patients with schizophrenia from healthy individuals, suggesting that it is a good candidate brain biomarker of schizophrenia.
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