Basic Science and Pathogenesis.

Background: Tau aggregation is the major cause of several neurodegenerative tauopathies. Tau interaction with other proteins affects the formation of tau aggregates with seeding activity but less is known about its effects on tau-seed properties. Our previous study revealed that Bassoon (BSN), a presynaptic protein, interacts with tau-seed, exacerbating its toxicity in vivo.

Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report.

An 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma.

LiNbHO: a new transition-metal oxyhydride with rock-salt-type structure.

Transition-metal oxyhydrides are an emerging class of functional materials; however, the known compounds have mostly been limited to perovskite-type sturctures. Here, we successfully synthesized LiNbHO, the first example of a rock-salt-type transition-metal oxyhydride, using mechanochemical methods. Galvanostatic charge/discharge tests revealed that LiNbHO functions as an electrode for lithium secondary batteries.