Publications by authors named "H Yagasaki"
It has been hypothesized that the biopsychosocial stress associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in combination with the immunological effects of SARS-CoV-2 and pancreatic β-cell dysfunction, may contribute to the onset of type 1 diabetes (T1D) in children. In this study, we documented the incidences of T1D in Yamanashi Prefecture, Japan, from 1986 to 2018, and expanded the analysis to include cases from 2019 to 2022 to evaluate the potential influence of coronavirus disease 2019 (COVID-19) on T1D incidence. The COVID-19 pandemic period was defined as 2020 to 2022.
View Article and Find Full Text PDFArticle Synopsis
- CHDED (Congenital Heart Defect and Ectodermal Dysplasia) is an autosomal dominant disorder linked to the PRKD1 gene, characterized by heart issues and ectodermal abnormalities.
- A case study of a 9-month-old Japanese girl demonstrated brain calcifications and seizures, revealing a new pathogenic variant in the PRKD1 gene.
- It is suggested that PRKD1, along with ITGB2 and JAM2, may interact through a common signaling pathway leading to brain calcifications, providing insight into the genetic basis of this disorder.
Leadless pacemakers (LPMs) offer an alternative for patients with challenging venous access or device infection history. Management of LPM battery depletion in frail patients presents unique challenges. We present the case of an 81-year-old frail woman with obstructive hypertrophic cardiomyopathy and complete heart block, previously treated with percutaneous transseptal myocardial ablation and a transvenous pacemaker, who received an LPM after device extraction for infection.
View Article and Find Full Text PDFArticle Synopsis
- * In a prospective study involving 95 subjects across 7 centers in Japan, the new system showed a high success rate in reducing MR and improving patient functional capacity.
- * Results indicated durable outcomes with minimal adverse events, including a low one-year all-cause mortality rate of 9.5% and heart failure hospitalization at 18.9%.
Mitral valve transcatheter edge-to-edge repair (M-TEER), a minimally invasive procedure that uses a clip to join the mitral valve leaflets, has emerged as an established treatment for severe mitral regurgitation (MR) in drug-refractory heart failure (HF). This case report presents an 80-year-old cardiac resynchronization therapy (CRT) non-responder with a complex cardiac history who underwent successful M-TEER. Despite optimal therapy, including CRT, she experienced recurrent HF symptoms.
View Article and Find Full Text PDF