A Rare Coexisting Presentation of Autosomal Dominant Polycystic Kidney Disease With Rapid Deterioration of Renal Function and Neurofibromatosis Type 1.

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney disorders, characterized by progressive cyst development. Neurofibromatosis type 1 (NF1) is another autosomal dominant disorder, characterized by café-au-lait spots, neurofibromas, and multisystem involvement. We report the case of an 18-year-old male with ADPKD and NF1, referred due to progressively worsening renal dysfunction.

Genetic and pharmacologic enhancement of SUMO2 conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer's disease.

Introduction: Amyloid beta oligomers (Aβos) are toxic to synapses and key to the progression of Alzheimer's disease (AD) and amyloid pathology, representing a target for therapeutic strategies.

Methods: Amyloid and small ubiquitin modifier 2 (SUMO2) transgenics were analyzed by electrophysiology and behavioral testing. A recombinant analogue of SUMO2, SBT02, was generated and assessed for brain penetration and the ability to mitigate amyloid pathology.

Effect of the ratio of water to rice on the molecular dynamics of cooked rice starch during retrogradation: Implications for amorphous structure in gelatinized state.

The ratio of water to rice during gelatinization affects starch retrogradation in cooked rice; a high ratio is more inhibitory to retrogradation. The structural state of the crystalline phase and also of the amorphous phase can be clarified by an indicator of molecular dynamics. In this study, we used quasi-elastic neutron scattering (QENS) to investigate the effect of the ratio of water to rice on the molecular dynamics of cooked rice starch during retrogradation.

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

Predicting Mastoid Extension and Complications such as Labyrinthine Fistula and Dural Exposure in Middle Ear Cholesteatoma Using Lesion Size and Detectability on Non-echo-planar Diffusion-weighted MR Imaging.

Purpose: This study aimed to quantitatively evaluate whether non-echoplanar diffusion-weighted MRI (non-EP DWI) lesion size and detectability can predict mastoid extension and complications such as labyrinthine fistula and dural exposure in middle ear cholesteatoma.

Methods: This retrospective study included 120 lesions with surgically confirmed middle ear cholesteatoma. Non-EP DWI was performed within 6 months preoperatively and evaluated for lesion detectability and size measurements, including maximum axial diameter, maximum axial area, and volume.