Publications by authors named "H Y Zhau"
Tumor cells gain advantages in growth and survival by acquiring genotypic and phenotypic heterogeneity. Interactions with bystander cells in the tumor microenvironment contribute to the progression of heterogeneity. We have shown that fusion between tumor and bystander cells is one form of interaction, and that tumor-bystander cell fusion has contrasting effects.
View Article and Find Full Text PDFBackground: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted cancer therapy may thwart the resistance to produce a substantial effect.
Methods: We tested whether the resistance can be circumvented by subcellular targeted cancer therapy with DZ-CIS, which is a chemical conjugate of the tumor-cell specific heptamethine carbocyanine dye (HMCD) with cisplatin (CIS), a chemotherapeutic drug with limited use in ccRCC treatment because of frequent renal toxicity.
Background: Lineage plasticity in prostate cancer (PCa) has emerged as an important mechanism leading to the onset of therapy- and castration-resistant PCa (t-CRPC), which is closely associated with cancer stem cell (CSC) activity. This study is to identify critical driver(s) with mechanism of action and explore new targeting strategy.
Methods: Various PCa cell lines with different genetic manipulations were subjected to in vitro prostasphere assay, cell viability assay and in vivo stemness potential.
Article Synopsis
- - Neuroendocrine prostate cancer (NEPC) often develops from castration-resistant prostate cancer (CRPC) and is a serious, rapidly progressive disease; understanding the transition mechanisms is essential for better treatment options.
- - Research shows that sphingosine kinase 1 (SphK1) is significantly implicated in the progression of NEPC and is regulated by the androgen receptor-REST complex, impacting the expression of neuroendocrine markers.
- - Inhibition of SphK1 was found to effectively reduce NEPC tumor growth and prevent REST protein degradation, suggesting that SphK1 inhibitors could become a targeted therapy for NEPC patients.
Background: Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis. The objective of this study is to elucidate the mechanism by which KRT13 promotes breast cancer growth and metastasis.
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