Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate.

The role of mitochondrial complex I (MC-I) dysfunction is well-documented across a range of neurodegenerative disorders. Recently, a novel positron emission tomography (PET) radioligand, [F]CNL02, has been synthesized to target MC-I. In this paper, we provide a comprehensive characterization of [F]CNL02, using nonhuman primate as a model system.

Selective Mu-Opioid Receptor Imaging Using F-Labeled Carfentanils.

Carfentanil, a highly potent synthetic opioid, paradoxically serves as a crucial positron emission tomography (PET) imaging tool in neurobiological studies of the mu-opioid receptor (MOR) system when labeled with carbon-11 ([C]CFN). However, its clinical research use is hindered by extreme potency and the limited availability of short-lived carbon-11 ( = 20.4 min).

Temperature overshoot responses to ambitious forestation in an Earth System Model.

Despite the increasing relevance of temperature overshoot and the rather ambitious country pledges on Afforestation/Reforestation globally, the mitigation potential and the Earth system responses to large-scale non-idealized Afforestation/Reforestation patterns under a high overshoot scenario remain elusive. Here, we develop an ambitious Afforestation/Reforestation scenario by harnessing 1259 Integrated Assessment Model scenarios, restoration potential maps, and biodiversity constraints, reaching 595 Mha by 2060 and 935 Mha by 2100. We then force the Max Planck Institute's Earth System Model with this scenario which yields a reduction of peak temperature by 0.

18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate.

Neuroimmune signaling is a key process underlying neuropathic pain. Clinical studies have demonstrated that 18 kDa translocator protein (TSPO), a putative marker of neuroinflammation, is upregulated in discrete brain regions of patients with chronic pain. However, no preclinical studies have investigated TSPO dynamics in the brain in the context of neuropathic pain and in response to analgesic treatments.