Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation.

Dysregulated energy metabolism, particularly lipid metabolism disorders, has been identified as a key factor in the development of diabetic cardiomyopathy (DCM). Sirtuin 2 (SIRT2) is a deacetylase involved in the regulation of metabolism and cellular energy homeostasis, yet its role in the progression of DCM remains unclear. We observed significantly reduced SIRT2 expression in DCM model mice.

Effects of expressive writing of positive emotions on mental health among patients with ovarian cancer undergoing postoperative chemotherapy.

Purpose: Patients with ovarian cancer often experience significant psychological distress during postoperative chemotherapy, including anxiety and depression. Expressive writing of positive emotions has shown potential in improving psychological health and fostering post-traumatic growth (PTG) in cancer patients. However, its application to ovarian cancer patients undergoing chemotherapy remains under-explored.

Improving soil properties and Sesbania growth through combined organic amendment strategies in a coastal saline-alkali soil.

Improving the quality of degraded coastal saline-alkali soil and promoting plant growth are key challenges in the restoration of ecological functions in coastal regions. Organic ameliorants such as effective microbial (EM) agent, biochar, and organic compost have been proposed as sustainable solutions, but limited research has explored the combined effects of these amendments. This study investigates five organic improvement strategies: individual applications of EM, corn straw biochar (CSB), and sewage sludge-reed straw compost (COM), along with combined treatments of CSB + EM and COM + EM, on Sesbania growth in a pot experiment.

Uncovering molecular mechanisms of soybean response to C heavy ion irradiation through integrated transcriptomic and metabolomic profiling.

Ion beam mutagenesis is an advanced technique capable of inducing substantial changes in plants, resulting in noticeable alterations in their growth. However, the precise molecular mechanisms underlying the effects of radiation on soybeans remain unclear. This study investigates the impact of ionizing radiation on soybean development through a comprehensive approach that integrates transcriptomics and metabolomics.

Ultrafast, Robust, and Reversible Self-Assembled Nanofibers via Thiolactone Chemistry Strategy.

Self-assembly in supramolecular chemistry is crucial for nanostructure creation but faces challenges like slow speeds and lack of reversibility. In this study, a novel comb-like polymer poly(amide sulfide) (PAS) based on thiolactone chemistry is reported, which rapidly self-assemble into stable nanofibers, offering excellent robustness and reversibility in the self-assembled structure. The PAS backbone contains pairs of amide bonds, each linked to an alkyl side chain in a controlled 2:1 ratio.