Advancements in the treatment of cerebral ischemia-reperfusion injury: Acupuncture combined with mesenchymal stem cells transplantation.

Cerebral ischemia-reperfusion injury (CIRI) constitutes a significant etiology of exacerbated cerebral tissue damage subsequent to intravenous thrombolysis and endovascular mechanical thrombectomy in patients diagnosed with acute ischemic stroke. The treatment of CIRI has been extensively investigated through a multitude of clinical studies. Acupuncture has been demonstrated to be effective in treating CIRI.

Transcriptional regulation of miR528-PPO module by miR156 targeted SPLs orchestrates chilling response in banana.

Banana is sensitive to cold stress and often suffers from chilling injury with browning peel and failure to normal ripening. We have previously reported that banana chilling injury is accompanied by a reduction of miR528 accumulation, alleviating the degradation of its target gene MaPPO and raising ROS levels that cause peel browning. Here, we further revealed that the miR528-MaPPO cold-responsive module was regulated by miR156-targeted SPL transcription factors, and the miR156c-MaSPL4 module was also responsive to cold stress in banana.

Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border.

Background: Polymerase delta-interacting protein 2 (Poldip2) is a novel regulator of vascular permeability that has been shown to be involved in aggravating blood-brain barrier (BBB) disruption following stroke; however, the underlying mechanisms are unknown. While endothelial tight junctions (TJ) are critical mediators of BBB permeability, the effect of Poldip2 on TJ function has not been elucidated yet. Here, we aim to define the mechanism by which Poldip2 mediates BBB disruption, specifically focusing on phosphorylation and stabilization of the TJ integral protein ZO-1.

One-Dimensional Excitonic Insulator of MTe (M = Mo, W) Atomic Wires.

Coulomb attraction with weak screening can trigger spontaneous exciton formation and condensation, resulting in a strongly correlated many-body ground state, namely, the excitonic insulator. One-dimensional (1D) materials natively have ineffective dielectric screening. For the first time, we demonstrate the excitonic instability of single atomic wires of transition metal telluride MTe (M = Mo, W), a family of 1D van der Waals (vdW) materials accessible in the laboratory.

Experimental Study on the Mechanism of Enhanced Imbibition with Different Types of Surfactants in Low-Permeability Glutenite Reservoirs.

Due to the complex physical properties of low-permeability glutenite reservoirs, the oil recovery rate with conventional development is low. Surfactants are effective additives for enhanced oil recovery (EOR) due to their good ability of wettability alteration and interfacial tension (IFT) reduction, but the reason why imbibition efficiencies vary with different types of surfactants and the mechanism of enhanced imbibition in the glutenite reservoirs is not clear. In this study, the imbibition efficiency and recovery of surfactants including the nonionic, anionic, and cationic surfactants as well as nanofluids were evaluated and compared with produced water (PW) using low-permeability glutenite core samples from the Lower Urho Formation in the Mahu oil field.