Publications by authors named "H Y Mo"
Study Question: What is the prevalence and trend of infertility among individuals of childbearing age at global, regional, and national levels by sex and socio-demographic index (SDI) across 21 regions and 204 countries and territories?
Summary Answer: Our findings reveal a growing prevalence of infertility among individuals aged 15-49 years worldwide from 1990 to 2021, with an expected continued increase through 2040.
What Is Known Already: Infertility is a persistent global reproductive health issue, leading to significant societal and health consequences. No study has specifically described the current prevalence of infertility, its secular trend, or the variations between regions or countries with different SDI levels.
Background: The fat mass and obesity-associated protein (FTO) has been showed to be involved in the pathogenesis and progression of coronary artery disease (CAD). However, the effects of FTO variants on CAD risk remain poorly understood. We herein genotyped three SNPs (rs1121980, rs72803657, and rs4783818) in FTO to investigate the influence of FTO polymorphisms on individual susceptibility to CAD.
View Article and Find Full Text PDFMetabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. Here, utilizing a metabolic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 knockout library screen, we observe that the loss of glutamate-cysteine ligase modifier subunit (GCLM), a rate-limiting enzyme in glutathione biosynthesis, noticeably increases the sensitivity of colorectal cancer (CRC) cells to platinum-based chemotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Efficient bifunctional transition metal phosphide catalysts, specifically RuCo co-doped NiP (RuCoNiP), were designed to improve hydrogen production technologies through one-step electrodeposition.
- The resulting structures, RuCoNiP@α-Ni(OH) and RuCoNiP@Co/Ni(OH), exhibited enhanced hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities and stabilities due to optimized adsorption properties and reduced energy barriers.
- A dual-electrode system utilizing RuCoNiP@α-Ni(OH) and RuCoNiP@Co/Ni(OH) achieved ultra-low battery voltage and impressive stability, highlighting the potential of this synthetic approach for efficient water-s
Purpose: The association between nutritional risk status assessment and hospital mortality in older patients remains controversial. The aim of this study was to assess the relationship between nutritional risk on admission and in-hospital mortality, and explore the best Nutritional Risk Status Screening 2002 (NRS2002) threshold for predicting in-hospital mortality of older inpatients in China.
Method: The elderly inpatients were recruited from a hospital in Hunan Province, China.