Prospects of elafibranor in treating alcohol-associated liver diseases.

Alcohol-related liver disease (ALD), which is induced by excessive alcohol consumption, is a leading cause of liver-related morbidity and mortality. ALD patients exhibit a spectrum of liver injuries, including hepatic steatosis, inflammation, and fibrosis, similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis, metabolic dysfunction-associated steatotic liver disease, and nonalcoholic steatohepatitis. Elafibranor has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and cell models of metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis.

Novel Dehydroabietylamine C-Ring Schiff Base Derivatives: Synthesis, Antiproliferative activity, DNA binding and Molecular docking.

A series of Dehydroabietylamine (DHAA) C-ring Schiff derivatives, L3-L20, were synthesized and their in vitro cytotoxic activity against the human tumor cell lines cervix HeLa, breast MCF-7, lung A549, liver HepG2, and the nonmalignant cell line umbilical vein HUVEC was investigated. Most of the compounds showed varying degrees of anticancer activity against HeLa cell lines while demonstrating lower toxicity to normal HUVEC cells compared to DHAA and doxorubicin (DOX), especially compound L19, which not only enhanced the anticancer activity of DHAA, but also significantly reduced the toxicity to normal cells, achieving a selectivity index (SI) 118 times higher than that of DHAA and 245 times higher than that of DOX. In addition, compound L19 induced apoptosis in HeLa cells in a dose-dependent manner and arrested the cell cycle in S phase.

Spirulina polysaccharides improve postthaw sperm quality in bulls by inhibiting the activation of pathways related to protein kinase A.

Sperm cryopreservation is widely used in assisted reproductive technology (ART) and livestock breeding. Although sperm cryopreservation accelerates breeding, the quality of cryopreserved sperm tends to be decreased. Improving the quality of frozen sperm is a hot topic, and spirulina polysaccharide, known for its immunomodulatory and antioxidant properties, is considered a promising natural extract for extensive studies.

An Optimized Bidirectional Long Short-Term Memory Model Based on Hyperspectral Analysis of Protein Content in Milk Powder.

Protein content is an important index in the assessment of dairy nutrition. As a crucial source of protein absorption in people's daily life, the quality of milk powder products not only has a deep impact on the development of the dairy industry, but also seriously damages the health of consumers. It is of great significance to find a faster and more accurate method for detecting milk protein content.

Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway.

Background: Acupuncture is an effective treatment for knee osteoarthritis (KOA), reducing pain and improving function. While melatonin (MLT) has notable pain relief benefits, the analgesic mechanism of acupuncture in KOA and its relationship with melatonin are still unknown. This study aims to explore this mechanism.