Comparing the effectiveness of different exercise interventions on quality of life in stroke patients: a randomized controlled network meta-analysis.

Background: This study evaluates the comprehensive impact of different exercise interventions on the quality of life in stroke patients through network meta-analysis, aiming to provide scientific evidence for developing more effective rehabilitation programs and improving patients' physical, psychological, and social functions.

Methods: This systematic review, registered in PROSPERO (CRD42024541517) and following PRISMA guidelines, searched multiple databases (PubMed, Web of Science, EMbase, Cochrane, Ebsco) until November 1, 2024. Studies were selected based on the PICOS criteria, including RCTs on stroke and exercise.

The whistle-blower effect vs. the cry-wolf effect: A game analysis framework for collaborative epidemic information governance.

The unpredictability of the epidemics caused by new, unknown viruses, combined with differing responsibilities among government departments, often leads to a prisoner's dilemma in epidemic information governance. In this context, the whistle-blower effect in the health departments leads to delayed reporting to avoid potential retaliation, and the cry-wolf effect in the administrative departments results in sustained observation to avoid ineffective warnings. To address these challenges, we employ game theory to analyze the dynamics of epidemic information governance and focus on two external governance mechanisms-superior accountability and media supervision-that can help resolve the prisoner's dilemma during and after an outbreak.

E-jet 3D printed aligned nerve guidance conduits incorporated with decellularized extracellular matrix hydrogel encapsulating extracellular vesicles for peripheral nerve repair.

Peripheral nerve injury (PNI) as a common clinical issue that presents significant challenges for repair. Factors such as donor site morbidity from autologous transplantation, slow recovery of long-distance nerve damage, and deficiencies in local cytokines and extracellular matrix contribute to the complexity of effective PNI treatment. It is extremely urgent to develop functional nerve guidance conduits (NGCs) as substitutes for nerve autografts.

DkGASA4 plays a role in the postharvest softening of persimmon fruit regulated by gibberellin.

Gibberellin (GA) is one of the crucial plant hormones involved in fruit ripening regulation. GASA genes, which respond to GA and encode cysteine-rich peptides, are prevalent in plants. While the GASA gene family has been identified in various plants, its role in persimmon fruit ripening remains unclear.

ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis.

We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary artery disease severity. Mechanistically, ABCA1-seRNA upregulated cholesterol efflux by interacting with mediator complex subunit 23 and recruiting retinoid X receptor-alpha and liver X receptor-alpha to promote ABCA1 transcription in a manner.