A Comparison of Short-Term Peripheral Nerve Stimulation and Pulsed Radiofrequency in the Treatment of Postherpetic Neuralgia.

Objective: To compare the application effects of short-term peripheral nerve stimulation (st-PNS) and pulsed radiofrequency (PRF) technology in postherpetic neuralgia (PHN).

Methods: A retrospective analysis was conducted on the clinical data of 127 PHN patients from our hospital. Based on the treatment interventions received, patients were divided into a control group (n=63, treated with PRF) and an observation group (n=64, treated with st-PNS).

Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis.

Background: Infectious episodes contribute to morbidity and mortality in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is frequently observed in AAV. Little is known about whether co-infection at initial diagnosis is associated with renal outcome and prognosis in children with AGN.

Application value of CT three-dimensional reconstruction technology in the identification of benign and malignant lung nodules and the characteristics of nodule distribution.

Objective: The study aimed to evaluate the application value of computed tomography (CT) three-dimensional (3D) reconstruction technology in identifying benign and malignant lung nodules and characterizing the distribution of the nodules.

Methods: CT 3D reconstruction was performed for lung nodules. Pathological results were used as the gold standard to compare the detection rates of various lung nodule signs between conventional chest CT scanning and CT 3D reconstruction techniques.

Concomitant medication effects on patients with lung cancer taking immune checkpoint inhibitors a review.

In the past decade, a variety of immune checkpoint inhibitors (ICIs) are currently approved for lung cancer in the world. As a new therapeutic approach, ICIs have shown significant clinical benefits in the first-line or second-line treatment for advanced lung cancer, improving the survival and quality of life of patients. Patients need to take multiple drugs in the meantime due to their own disease or side effects during treatment.

Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells.

Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding epigenetic regulatory pathways. Peptide- or protein-based histone photoaffinity tools expanded the ability to probe the epigenetic interactome, but in situ profiling in native cells remains challenging. Here, we develop a nucleus-targeting histone-tail-based photoaffinity probe capable of profiling the hPTM-mediated interactomes in native cells, by integrating cell-permeable and nuclear localization peptide modules into an hPTM peptide equipped with a photoreactive moiety.