Publications by authors named "H Wulff"
The calcium-activated K3.1 channel plays a crucial role in T-cell immune response. Genetic manipulation of T-cells to upregulate the expression of K channels has been shown to boost T-cell cytotoxicity in cancer.
View Article and Find Full Text PDFIntroduction: Sociodemographic factors such as parental education level (ED) influence the physical activity (PA) and sedentary behavior (SED) of primary school-aged children. In this context, family factors, such as the physical activity-related Family Health Climate (FHC), are relevant. However, the effect of FHC on the interaction between ED and children's activity behavior has not yet been investigated.
View Article and Find Full Text PDFBackground: Riluzole exhibits neuroprotective and therapeutic effects in several neurological disease models associated with excessive synaptic glutamate (Glu) release. We recently showed riluzole prevents acute excitotoxic hippocampal neural injury at 3 days in the kainic acid (KA) model of temporal lobe epilepsy (TLE). Currently, it is unknown if preventing acute neural injury and the neuroinflammatory response is sufficient to suppress epileptogenesis.
View Article and Find Full Text PDFArticle Synopsis
- Structure-based virtual screening is essential in early drug discovery, relying on accurate predictions of how compounds bind to targets.
- The new method, RosettaVS, improves prediction accuracy by incorporating receptor flexibility and outperforms existing approaches, resulting in successful hits in screening multi-billion compound libraries.
- Using this platform, the study identified multiple promising compounds for two different protein targets, with validation achieved through high-resolution X-ray crystallography, confirming the method’s effectiveness in finding new drug leads.
Objective: This study tested the hypothesis that administration of the KCa channel activator SKA-31 restores endothelium-dependent vasodilation in vivo in Type 2 Diabetic (T2D) rats.
Background: Acute treatment of isolated resistance arteries from T2D rats and humans with SKA-31 significantly improved endothelium-dependent vasodilation. However, it is unknown whether these in situ actions translate to intact vascular beds in vivo.