Axial shift mapping: a self-referencing test for measuring the axial figure of near-cylindrical surfaces.

Lateral shearing self-referencing interferometry methods shift the surface under test between measurements to separate its topography from that of the reference surface. However, rigid body errors occur during shifting, creating an ambiguity in the quadratic term of the extracted surfaces. We present axial shift mapping, a lateral shearing self-referencing interferometry method for cylinders, in which the quadratic ambiguity is resolved by measuring the rigid body errors using known artifact mirrors residing in the interferometer's field of view.

Interferometric metrology probe for highly sloped freeform optics.

A wide variety of systems are employed to measure the surface profile of aspheric and freeform optical surfaces. Freeform metrology systems must accurately characterize the full surface under test, which can be difficult with steep surface slopes. Here we present an interferometric surface metrology probe for highly sloped aspheric and freeform optical surfaces.

Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications.

Over the past few decades, DNA has been recognized as a powerful self-assembling material capable of crafting supramolecular nanoarchitectures with quasi-angstrom precision, which promises various applications in the fields of materials science, nanoengineering, and biomedical science. Notable structural features include biocompatibility, biodegradability, high digital encodability by Watson-Crick base pairing, nanoscale dimension, and surface addressability. Bottom-up fabrication of complex DNA nanostructures relies on the design of fundamental DNA motifs, including parallel (PX) and antiparallel (AX) crossovers.

Combining digital pill and smartphone data to quantify medication adherence in an observational psychiatric pilot study.

Digital medicine systems (DMSs) offer a potential solution to increase medication adherence, which is an important barrier to treatment of psychiatric disorders. In this pilot, we enrolled N = 24 individuals diagnosed with severe mental illness to use an FDA-approved DMS for 5 months. We also collected digital phenotyping smartphone data to study behavioral associations with medication adherence.

Recent Advances in Self-Assembled DNA Nanostructures for Bioimaging.

DNA nanotechnology has been proven to be a powerful platform to assist the development of imaging probes for biomedical research. The attractive features of DNA nanostructures, such as nanometer precision, controllable size, programmable functions, and biocompatibility, have enabled researchers to design and customize DNA nanoprobes for bioimaging applications. However, DNA probes with low molecular weights (e.