Tetra-Cationic Distibane Stabilized by Bis(α-iminopyridine) and Its Reactivity.

The work establishes the salt of a tetra-cationic distibane, [LSb][CFSO] = [][OTf] (CFSO = OTf), stabilized by a bis(α-iminopyridine) ligand , defying the Coulombic repulsion. The synthetic approach involved a dehydrocoupling reaction when a mixture of and Sb(OTf) in a 1:1 ratio was treated with EtSiH/LiBEtH as the hydride source. Compound [][OTf] was also achieved from [LSbCl][OTf] as a precursor and using EtSiH.

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New Media and Addiction in Youth New media, such as digital games, social media, and video streaming services, have emerged as fundamental channels for socialization and leisure activities among young people. Platforms such as TikTok, Fortnite, and YouTube do not only provide entertainment, enjoyment, and opportunities for social connection, but also carry the risk of excessive use. Particularly vulnerable youth, who turn to media to escape real-world problems and conflicts, can quickly become trapped in a vicious cycle, resulting in problematic usage habits with significant psychosocial consequences.

Monitoring nucleolar-nucleoplasmic protein shuttling in living cells by high-content microscopy and automated image analysis.

The nucleolus has core functions in ribosome biosynthesis, but also acts as a regulatory hub in a plethora of non-canonical processes, including cellular stress. Upon DNA damage, several DNA repair factors shuttle between the nucleolus and the nucleoplasm. Yet, the molecular mechanisms underlying such spatio-temporal protein dynamics remain to be deciphered.

Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements.

Lipid droplet (LD) function relies on proteins partitioning between the endoplasmic reticulum (ER) phospholipid bilayer and the LD monolayer membrane to control cellular adaptation to metabolic changes. It has been proposed that these hairpin proteins integrate into both membranes in a similar monotopic topology, enabling their passive lateral diffusion during LD emergence at the ER. Here, we combine biochemical solvent-accessibility assays, electron paramagnetic resonance spectroscopy and intra-molecular crosslinking experiments with molecular dynamics simulations, and determine distinct intramembrane positionings of the ER/LD protein UBXD8 in ER bilayer and LD monolayer membranes.

Towards high performance dielectric microwave resonators for X-band EPR spectroscopy.

Microwave (MW) resonators in Electron Paramagnetic Resonance (EPR) spectroscopy concentrate the MW magnetic field (B) at the sample and separate the MW electric field from the sample. There are numerous experimental methods in EPR spectroscopy which all impose different requirements on MW resonators (e.g.