Cyclosporine A Delays the Terminal Disease Stage in the Tfam KO Mitochondrial Myopathy Mouse Model Without Improving Mitochondrial Energy Production.

Introduction And Aims: Mitochondrial myopathies are rare genetic disorders for which no effective treatment exists. We previously showed that the pharmacological cyclophilin inhibitor cyclosporine A (CsA) extends the lifespan of fast-twitch skeletal muscle-specific mitochondrial transcription factor A knockout (Tfam KO) mice, lacking the ability to transcribe mitochondrial DNA and displaying lethal mitochondrial myopathy. Our present aim was to assess whether the positive effect of CsA was associated with improved in vivo mitochondrial energy production.

Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression.

Prolonged low-frequency force depression (PLFFD) is an intramuscular phenomenon involving the slow recovery of submaximal muscle strength following strenuous exercise. We hypothesize that the contribution of impaired excitation-contraction coupling processes to PLFFD is task dependent, and that they will be different between metabolically and mechanically demanding exercises. We also discuss evidence of the effectiveness of interventions to mitigate PLFFD.

The impact of bisphenol AF on skeletal muscle function and differentiation in vitro.

Various environmental chemicals have been identified as contributors to metabolic diseases. Bisphenol AF (BPAF), a substitute for bisphenol A, has been associated with changes in glucose metabolism and incidence of type 2 diabetes mellitus in humans. However, its mode of action remains unclear.