Pediatric Cancer Communication on Twitter: Natural Language Processing and Qualitative Content Analysis.

Background: During the COVID-19 pandemic, Twitter (recently rebranded as "X") was the most widely used social media platform with over 2 million cancer-related tweets. The increasing use of social media among patients and family members, providers, and organizations has allowed for novel methods of studying cancer communication.

Objective: This study aimed to examine pediatric cancer-related tweets to capture the experiences of patients and survivors of cancer, their caregivers, medical providers, and other stakeholders.

Chlorfenapyr Crystal Polymorphism and Insecticidal Activity.

Four crystalline polymorphs of the proinsecticide chlorfenapyr [4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethyl-1-pyrrole-3-carbonitrile] have been identified and characterized by polarized light optical microscopy, differential scanning calorimetry, Raman spectroscopy, X-ray diffraction, and electron diffraction. Three of the four structures were considered polytypic. Chlorfenapyr polymorphs show similar lethality against fruit flies () and mosquitoes () with the least stable polymorph showing slightly higher lethality.

Emergent Self-Assembly of Sustainable Plastics Based on Amino Acid Nanocrystals.

Development of biodegradable plastic materials is of primary importance in view of acute environmental and health problems associated with the accumulation of plastic waste. We fabricated a biodegradable composite material based on hydroxyethyl cellulose polymer and tyrosine nanocrystals, which demonstrates enhanced strength and ductility (typically mutually excluding properties), superior to most biodegradable plastics. This emergent behavior results from an assembly pattern that leads to a uniform nanoscale morphology and strong interactions between the components.

Adjustable Fluorescence Emission of J-Aggregated Tricarbocyanine in the Near-Infrared-II Region.

Near-infrared (NIR) J-aggregates attract increasing attention in many areas, especially in biomedical applications, as they combine the advantages of NIR spectroscopy with the unique J-aggregation properties of organic dyes. They enhance light absorption and have been used as effective biological imaging and therapeutic agents to achieve high-resolution imaging or effective phototherapy in vivo. In this work, we present novel J-aggregates composed of the well-known cyanine molecules.

Designed active-site library reveals thousands of functional GFP variants.

Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantially reducing the likelihood of obtaining functional multipoint mutants. We introduce an atomistic and machine-learning-based approach, called high-throughput Functional Libraries (htFuncLib), that designs a sequence space in which mutations form low-energy combinations that mitigate the risk of incompatible interactions.