Publications by authors named "H Weinstein"
Background: Public health professionals are crucial in implementing health-promoting climate change adaptation and mitigation measures, yet climate education is inconsistently integrated into public health curricula worldwide. We aimed to assess the proportion of institutions that provided public health degrees with climate and health education, the annual number of students trained in climate and health, and the extent to which students had climate and health knowledge during 2023-24.
Methods: From Nov 1, 2023, to March 15, 2024, our online survey quantified climate and health education in public health schools that provide degrees across all WHO regions.
Microsatellite instability-high (MSI-H) tumors are malignant tumors that, despite harboring a high mutational burden, often have intact TP53. One of the most frequent mutations in MSI-H tumors is a frameshift mutation in RPL22, a ribosomal protein. Here, we identified RPL22 as a modulator of MDM4 splicing through an alternative splicing switch in exon 6.
View Article and Find Full Text PDFBackground: Transforaminal epidural injections with steroids (TESI) are increasingly being used in patients sciatica. The STAR (steroids against radiculopathy)-trial aimed to evaluate the (cost-) effectiveness of TESI in patients with acute sciatica (< 8 weeks). This article contains the economic evaluation of the STAR-trial.
View Article and Find Full Text PDFArticle Synopsis
- The SARS-CoV-1 spike glycoprotein's fusion peptide (FP) interacts with calcium ions to enhance its ability to fuse viral and host cell membranes, with specific negatively charged residues playing key roles.
- Mutations in these residues demonstrated that certain combinations, particularly D802 and D830, are crucial for effective cell entry and syncytia formation, while odd mutations can either hinder or slightly improve these processes.
- Molecular dynamics simulations helped identify preferred calcium binding pairs that facilitate or inhibit membrane insertion, revealing that calcium binding can help the FP adopt shapes that minimize repulsion from host cell membranes.
Author's Reply to the Letter of Van Boxem, Van Gaag, Van Zundert, and Kallewaard, Entitled 'Response to Ter Meulen et al. Effect of Transforaminal Epidural Corticosteroid Injections in Acute Sciatica'.
Clin J Pain
March 2024