Publications by authors named "H Wakayama"
Article Synopsis
- Researchers have developed thermoresponsive mixed polymer brushes using PNIPAAm and PDMAPAAm to control cell adhesion properties for tissue engineering applications.
- These polymer brushes can switch their surface properties based on temperature, enhancing or reducing cell adhesion, particularly at body temperature (37°C).
- This technology allows for the selective separation of specific cell types, like mesenchymal stem cells, from others by simply adjusting the temperature, showcasing its potential for regenerative medicine.
In preclinical drug testing, human muscle tissue models are critical to understanding the complex physiology, including drug effects in the human body. This study reports that a multilayering approach to cell sheet-based engineering produces an engineered human muscle tissue with sufficient contractile force suitable for measurement. A thermoresponsive micropatterned substrate regulates the biomimetic alignment of myofiber structures enabling the harvest of the aligned myofibers as a single cell sheet.
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- - A 73-year-old Japanese man was diagnosed with acute myeloid leukemia (AML) but also had splenomegaly and a liver tumor, raising questions about his diagnosis.
- - To clarify the situation, doctors performed splenectomy and liver surgery, which revealed abnormal lymphoid cells in the tissue that were CD3-positive but did not show T-cell receptor (TCR) rearrangement.
- - The case could not be classified as hepatosplenic T-cell lymphoma due to the lack of TCR expression, despite similar clinical features, highlighting the complexity of his condition.
The present paper proposes an adaptive control law for inducing in-phase and antiphase synchronization in a pair of relaxation oscillators. We analytically show that the phase dynamics of the oscillators coupled by the control law is equivalent to that of Kuramoto phase oscillators and then extend the results for a pair of oscillators to three or more oscillators. We also provide a systematic procedure for designing the controller parameters for oscillator networks with all-to-all and ring topologies.
View Article and Find Full Text PDFBoth hypocellular leukemia and Philadelphia (Ph) chromosome-positive mixed-phenotype acute leukemia (MPAL) are rare subtypes of leukemia showing unfavorable outcomes and lacking established optimal management. Ph-positive leukemia most often presents with hypercellularity and hypoplasia is a rare condition. The present study reports an extremely rare case of hypocellular biclonal Ph-positive MPAL, which was diagnosed by biopsy and genetic analysis of bone marrow, and successfully treated with dasatinib and steroids.
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