Lifting the veil off treatment effect heterogeneity.

Clinicians often suspect that a treatment effect can vary across individuals. However, they usually lack "evidence-based" guidance regarding potential heterogeneity of treatment effects (HTE). Potentially actionable HTE is rarely discovered in clinical trials and is widely believed (or rationalized) by researchers to be rare.

An Evaluation of a Telehealth Caregiver Training Package to Treat Food Selectivity.

Telehealth behavioral interventions are increasingly necessary when in-person services are not accessible (e.g., due to geographic location, time, cost, and health and safety restrictions).

The effects of antipsychotic medications on microbiome and weight gain in children and adolescents.

Background: Atypical antipsychotics, also known as second-generation antipsychotics, are commonly prescribed as treatment for psychotic disorders in adults, as well as in children and adolescents with behavioral problems. However, in many cases, second-generation antipsychotics have unwanted side effects, such as weight gain, potentially further increasing risk for morbidities including obesity, diabetes, and cardiovascular disease. While various mechanisms for this weight gain have been proposed, including effects on metabolic hormone signaling, recent evidence points to the importance of the gut microbiome in this process.

Individualizing Intervention to Teach Joint Attention, Requesting, and Social Referencing to Children with Autism.

Social communication skills such as joint attention (JA), requesting, and social referencing (SR) are deficits in children with autism spectrum disorder (ASD). Shifting gaze is a common response across these skills. In many studies, children respond variably to intervention, resulting in modifications to planned intervention procedures.

Dispositional Optimism and Cardiovascular Reactivity Accompanying Anger and Sadness in Young Adults.

Background: Dispositional optimism, a generalized expectation for positive outcomes, appears to promote physical health and well-being, including positive effects on cardiovascular disease outcomes. Mechanisms may involve adaptive responses to psychological stressors that dampen their physiological impact.

Purpose: This study investigated (i) whether individual differences in optimism are associated with attenuated cardiovascular reactivity (CVR); (ii) whether the CVR moderating effect of optimism differs for two stress emotions, anger and sadness; and (iii) whether separate measures of optimism and pessimism, and the more commonly used measure that combines them, differ in their relationships with CVR.