Publications by authors named "H W Whitford"
Pulmonary arterial hypertension (PAH) is a rare condition for which a remarkable change has been witnessed in the epidemiology, assessment and treatment landscape over the last three decades. Well-established registries from the Western world have not only highlighted the shift in the epidemiology to an older, more comorbid cohort but have also identified markers of prognosis that have been validated as part of risk stratification scores in multiple cohorts. The emphasis on early identification through a systematic assessment pathway and the option of upfront combination therapy with serial risk stratification assessment has laid the foundation for the standard of care and improved prognosis.
View Article and Find Full Text PDFArticle Synopsis
- - Chronic thromboembolic pulmonary disease (CTEPD), especially when complicated by pulmonary hypertension (CTEPH), is a serious condition linked to venous blood clots that can lead to high morbidity and mortality if left untreated.
- - Treatment options for CTEPD and CTEPH include pulmonary endarterectomy (PEA), balloon pulmonary angioplasty, and medical therapy, with the choice depending on factors like disease severity and patient health.
- - The manuscript reviews the history and outcomes of PEA in Australasia, offering guidance on its use in treatment and discussing future challenges and opportunities in diagnosing and managing CTEPD and CTEPH in that region.
Article Synopsis
- Frailty is common among lung transplant candidates, and this study explores how frailty changes during the first year after the transplant.
- Participants underwent a 12-week exercise rehabilitation program, and their frailty was assessed using the Edmonton Frail Scale (EFS) throughout the process.
- Results showed significant improvements in physical capacity (measured by 6-Minute Walk Distance) and mental health outcomes for all participants, suggesting that pre-transplant frailty may improve with rehabilitation and should not prevent individuals from receiving a lung transplant.
Advances in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) over the past decade changed the disease landscape, yet global insight on clinical practices remains limited. The CTEPH global cross-sectional scientific survey (CLARITY) aimed to gather information on the current diagnosis, treatment, and management of CTEPH and to identify unmet medical needs. This paper focuses on the treatment and management of CTEPH patients.
View Article and Find Full Text PDFEarly recognition and diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is crucial for improving prognosis and reducing the disease burden. Established clinical practice guidelines describe interventions for the diagnosis and evaluation of CTEPH, yet limited insight remains into clinical practice variation and barriers to care. The CTEPH global cross-sectional scientific survey (CLARITY) was developed to gather insights into the current diagnosis, treatment, and management of CTEPH and to identify unmet medical needs.
View Article and Find Full Text PDF