Oxidized polyunsaturated fatty acid promotes colitis and colitis-associated tumorigenesis in mice.

Background And Aims: Human studies suggest that a high intake of polyunsaturated fatty acid (PUFA) is associated with an increased risk of inflammatory bowel disease (IBD). PUFA is highly prone to oxidation. To date, it is unclear whether unoxidized or oxidized PUFA is involved in the development of IBD.

Assessing the psychometric properties of the Army STARRS' vertical unit cohesion scale: A large-scale, longitudinal study.

Unit cohesion is the extent to which military service members feel committed to and supported by their military unit or, conversely, feel overlooked, neglected, and/or alienated. Unit cohesion reflects an important aspect of military social support and can act as a protective factor against mental health challenges, particularly in challenging situations. Theoretical suppositions and emerging evidence suggest that different types of unit support, specifically, and , uniquely matter for service member well-being.

LKB1 isoform expression modulates T cell plasticity downstream of PKCθ and IL-6.

Following activation, CD4 T cells undergo metabolic and transcriptional changes as they respond to external cues and differentiate into T helper (Th) cells. T cells exhibit plasticity between Th phenotypes in highly inflammatory environments, such as colitis, in which high levels of IL-6 promote plasticity between regulatory T (Treg) cells and Th17 cells. Protein Kinase C theta (PKCθ) is a T cell-specific serine/threonine kinase that promotes Th17 differentiation while negatively regulating Treg differentiation.

Rethinking Conservative Treatment of Humeral Diaphyseal Fractures in Elderly Patients With Dementia.

Objectives: To assess outcomes and complications of conservatively managed humeral diaphyseal fractures in elderly patients, with an emphasis on the subgroup diagnosed with dementia.

Design: Retrospective.

Setting: Upper extremity surgery unit at an academic Level I trauma center.

Correction: Huang et al. A Next Generation Sequencing-Based Protocol for Screening of Variants of Concern in Autism Spectrum Disorder. 2022, , 10.

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