Publications by authors named "H W NITSCHKE"

Article Synopsis
  • Fusidic acid is a steroid antibiotic used topically for skin infections caused by Staphylococcus aureus, particularly in the face of increasing methicillin-resistant strains (MRSA) that possess specific resistance genes.
  • The study explored MRSA isolates from the Arabian Gulf, revealing previously unreported variants of SCCmec elements with the fusC resistance gene, suggesting complex genetic relationships among strains from different countries.
  • The findings indicate that MRSA strains with these resistance genes may have a competitive advantage in healthcare and community environments, highlighting the need to reconsider the use of topical antibiotics and restrict their sale without prescriptions.
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SCCmec elements are very important mobile genetic elements in Staphylococci that carry beta-lactam resistance genes mecA/mecC, recombinase genes and a variety of accessory genes. Twelve main types and a couple of variants have yet been described. In addition, there are also other SCC elements harbouring other markers.

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The Cologne statement resulted from both regional and nationwide controversial discussions about meaning and purpose of an initial examination for infectious diseases of refugees with respect to limited time, personnel and financial resources. Refugees per se are no increased infection risk factors for the general population as well as aiders, when the aiders comply with general hygiene rules and are vaccinated according to the recommendations of the German Standing Committee on Vaccination (STIKO). This is supported by our own data.

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Refugees continue seeking sanctuary in Germany and it can reasonably be expected that their health will be affected by the conditions they lived in before and during flight. Ensuring nationwide care for refugees should be demand oriented, effective and efficient, which requires tackling mostly similar challenges a community level in a consistent manner. The aim must be providing adequate medical care based on the principle of respect for human dignity and ensuring public health standards.

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Streptococcus agalactiae frequently colonizes the urogenital tract, and it is a major cause of bacterial septicemia, meningitis, and pneumonia in newborns. For typing purposes, a microarray targeting group B streptococcus (GBS) virulence-associated markers and resistance genes was designed and validated with reference strains, as well as clinical and veterinary isolates. Selected isolates were also subjected to multilocus sequence typing.

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