Phage therapy for extensively drug resistant infection: case report and evaluation of the distribution of phage and the impact on gut microbiome.

Numerous studies have documented successful instances of bacteriophage therapy in treating infections caused by extensively drug-resistant (XDRAB). However, the safety profile of phage therapy and its effects on the human gut microbiota remain areas of concern. In this study, we collected blood, sputum, and fecal samples from an elderly female patient during two phases of inhaled bacteriophage therapy targeting extensively drug-resistant (XDRAB).

Disease burden and trends of lung cancer attributable to nickel among Chinese and global population: a cross-sectional study.

Background: Nickel is a well-established carcinogen, and China stands as a significant producer of nickel compounds. Nickel-associated lung cancer is increasingly acknowledged as a pressing public health concern. This study presents a comprehensive analysis at temporal, spatial, and population levels utilizing the most recent data from GBD 2019 to estimate the disease burden of nickel-associated lung cancer from 1990 to 2019, and make predictions to 2035.

Development of a two-component recombinant vaccine for COVID-19.

Introduction: Though COVID-19 as a public health emergency of international concern (PHEIC) was declared to be ended by the WHO, it continues to pose a significant threat to human society. Vaccination remains one of the most effective methods for preventing COVID-19. While most of the antigenic regions are found in the receptor binding domain (RBD), the N-terminal domain (NTD) of the S protein is another crucial region for inducing neutralizing antibodies (nAbs) against COVID-19.

High-Aspect-Ratio InGaO Integrated with Amorphous AlO Nanofibers: All-Inorganic Self-Supporting Wearable Membranes for Ultralow-Concentration NO Sensing in Simulated Exhalation.

Achieving high flexibility, breathability, and sensitivity in inorganic semiconductor gas sensors remains a substantial challenge, especially for wearable applications in high-humidity environments. This study develops a hyper-flexible, thermally stable, and highly breathable full-inorganic, self-supporting InGaO-AlO/AlO nanofiber membrane sensor, fabricated using a dual-spinneret electrospinning method with an interlocking design. This innovative sensor has a bilayer structure with an amorphous AlO nanofiber substrate layer supporting an active layer of high-aspect-ratio interwoven InGaO and AlO nanofibers, providing outstanding flexibility, elevated breathability, and strong thermal stability.

Two-year follow-up of dementia caregivers after a digital health intervention WECARE: a mixed-method study.

Objectives: Few digital health interventions for dementia caregivers, especially for racial and ethnic minorities, include long-term follow-ups. This study assessed the feasibility of two-year follow-up of the Wellness Enhancement for Caregivers (WECARE) intervention for Chinese American dementia caregivers, examined the changes in psychosocial health and explored future strategies.

Method: A mixed-method study was conducted two years after the initial WECARE intervention trial.