Publications by authors named "H W Hunt"
In this work, we designed novel peptide conjugates with plant-based iridoid and lichen-derived depside derivatives to target the wild-type EGFR (WT) and its mutants, L858R and T790M/L858R/C797S triple mutant. These mutations are often expressed in multiple cancers, particularly lung cancer. Specifically, the iridoids included 7-deoxyloganetic acid (7-DGA) and loganic acid (LG), while the depside derivative was sekikaic acid (SK).
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- The study aimed to assess the occurrence of subclinical cardiomyopathy and cardiac-related deaths in a colony of non-purebred cats in New Zealand as a representation of the general cat population.
- A total of 132 cats underwent physical exams and echocardiography, revealing that 18.2% had heart disease, primarily hypertrophic cardiomyopathy (HCM), while 24% exhibited heart murmurs.
- Over a ten-year period, heart disease was determined to be the cause of death in 5.3% of the cat population studied, with a specific prevalence of HCM-related deaths at 3.8%.*
Recently, hypertrophic cardiomyopathy (HCM) in Sphynx cats has been associated with a variant in the gene encoding Alström syndrome protein 1 (ALMS1). The primary aims of this study were to describe the prevalence of HCM in Sphynx cats in New Zealand, and to assess the association between HCM and the ALMS1 variant in this population. In this prospective study, 55 apparently healthy Sphynx cats from registered Sphynx breeders and pet owners in New Zealand were screened by a cardiologist.
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- This research used a biomimetic strategy to target KATO (III) tumor cells and 3D tumoroids by exploring the binding of two bioactive peptides, ACSAG and LPHVLTPEAGAT, to the fibroblast growth factor receptor 2 (FGFR2).
- A new fused trimer peptide, ACSAG-LPHVLTPEAGAT-GASCA, was developed and shown to effectively bind to FGFR2, using molecular simulations to identify key interactions within the receptor's structure.
- The peptides, especially when conjugated with Doxorubicin, demonstrated higher cytotoxicity in gastric cancer cells compared to normal cells, and the conjugates showed promising permeation in 3D