Intermittent high permeability hemofiltration in septic patients with acute renal failure.

Objective: High permeability hemofiltration (HP-HF) is a new renal replacement modality designed to facilitate the elimination of cytokines in sepsis. Clinical safety data on this new procedure is still lacking. This study investigates the effects of HP-HF on the protein and coagulation status as well as on cardiovascular hemodynamics in patients with septic shock.

[Indications for the Scribner shunt in hemodialysis].

The indication to a Scribner shunt as vascular access for hemodialysis has been reduced significantly by the use of central-venous catheters and creation of subcutaneous access methods. In 13 patients suffering from septic complications of the central-venous vascular access catheters a Scribner shunt was created for continuation of hemodialysis. After removal of infected catheters and specific antibiotic therapy the sepsis could be controlled in 12 patients within 4-18 days.

[Straight upper arm arteriovenous implants of allogenic vascular transplant material in various hemodynamic conditions].

Studies were conducted into the effects of various forms of flow reduction upon both pressure in shunt and functional properties of 134 arteriovenous bridging grafts on the upper arm for haemodialysis of deantigenised, form-fixed, preserved segments of varicose veins with silicone-coated inner surfaces. Strongest pressure reduction and best clinical results were obtained from composite grafts with a short, narrow segment on the inflow side.

[Saralasin test in the differential diagnosis of essential and renal hypertension].

In a multicentric prospective study should be tested clinically the effectiveness and the tolerance of an angiotensin-II-antagonist (Saralasin-IWF) developed by the Institut für Wirkstofforschung der Akademie der Wissenschaften, its position in the differential-diagnostic step programme of the arterial hypertension should be analysed and with it should be performed pathogenetic investigations for hypertension after kidney transplantation. Taking into consideration international studies our results confirm that the Saralasin test, taking into account strongly standardized methodical prerequisites, is suited to objectify a participation of the RAAS in the hypertension pathogenesis, without, however, thus making an absolutely reliable evidence concerning the etiology of hypertension. The Saralasin test may represent an important diagnostic criterion for an optimization of the therapy of "volume-resistant" hypertension under the conditions of haemodialysis and in connection with selective renin determinations it possesses a high value in the screening diagnostics of the arterial stenosis after allogenic kidney transplantation.