Publications by authors named "H Vorng"
Nucleotide-binding oligomerization domain 2 (NOD2) recognizes pathogens associated with the development of asthma. Moreover, NOD2 adjuvants are used in vaccine design to boost immune responses. Muramyl di-peptide (MDP) is a NOD2 ligand, which is able to promote Th2/Th17 responses.
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- * The study focused on CCL18, a chemokine linked to allergic diseases, revealing that it effectively stimulates NK cell migration and cytotoxicity in nonallergic individuals but not in those with allergies.
- * NK cells from allergic patients did not respond to CCL18, indicating a potential defect in their immune functions, while the inability to respond was not due to a problem with CCL18 binding.
Article Synopsis
- Scientists studied how certain bacteria might make asthma worse through a special body sensor called NOD1.
- They used a model of asthma caused by dust mites to see what happens without this sensor.
- The research found that when NOD1 is turned off, asthma symptoms get better, and this could lead to new ways to treat asthma.
Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity.
J Allergy Clin Immunol
November 2016
Background: Epidemiologic and clinical observations identify obesity as an important risk factor for asthma exacerbation, but the underlying mechanisms remain poorly understood. Type 2 innate lymphoid cells (ILC2s) and type 3 innate lymphoid cells (ILC3s) have been implicated, respectively, in asthma and adipose tissue homeostasis and in obesity-associated airway hyperresponsiveness (AHR).
Objective: We sought to determine the potential involvement of innate lymphoid cells (ILCs) in allergic airway disease exacerbation caused by high-fat diet (HFD)-induced obesity.