Quantifying memory deficits in amnestic mild cognitive impairment.

Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI).

Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test.

Results: The results revealed clear differences in recall performance between patients with aMCI and controls.

Concordance between brain F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease.

Objectives: Cortical posterior hypometabolism on PET imaging with F-FDG (FDG-PET), and altered levels of Aß peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD.

Material And Methods: A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers.