Left Ventricle Size Correlates with Peak Exercise Capacity in Pediatric Cancer Survivors Exposed to Anthracycline Chemotherapy.

Cancer survivors exposed to anthracycline chemotherapy are at risk for developing cardiomyopathy, which may have delayed clinical manifestation. In a retrospective cross-sectional study, we evaluated the utility of cardiopulmonary exercise testing (CPET) for detecting early cardiac disease in 35 pediatric cancer survivors by examining the associations between peak exercise capacity (measured via percent predicted peak VO) and resting left ventricular (LV) function on echocardiography and cardiac magnetic resonance imaging (cMRI). We additionally assessed the relationships between LV size on resting echocardiography or cMRI and percent predicted peak VO since LV growth arrest can occur in anthracycline-exposed patients prior to changes in LV systolic function.

The role of ATXR6 expression in modulating genome stability and transposable element repression in .

ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) AND ATXR6 are required for the deposition of H3K27me1 and for maintaining genomic stability in Reduction of ATXR5/6 activity results in activation of DNA damage response genes, along with tissue-specific derepression of transposable elements (TEs), chromocenter decompaction, and genomic instability characterized by accumulation of excess DNA from heterochromatin. How loss of ATXR5/6 and H3K27me1 leads to these phenotypes remains unclear. Here we provide extensive characterization of the hypomorphic mutant by comprehensively examining gene expression and epigenetic changes in the mutant.

[How did I contract human Papillomavirus (HPV)?].

More than 120 genotypes have been identified among the Papillomavirus (HPV) family. These viruses are ubiquitary with skin or mucous membrane tropism and cause various pathologies from wart to neoplasia. HPV family is classified according to their tropism.

In situ net mineralization rates in a heterogeneous mixed deciduous forest receiving elevated n deposition.

In situ net mineralization was studied at 6 locations (E, Eb, Ec, F1, F2, F3) of a heterogeneous mixed deciduous forest ("De Gulkeputten") with oak (Quercus robur L., Quercus rubra) and birch (Betula pendula) as dominant species. Net nitrogen mineralization was determined by means of a sequential in situ incubation experiment using intact soil cores.