Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges.

Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics.

Deciphering the role of exosomal derived regulatory noncoding RNAs as potential biomarkers for diabetic retinopathy: a systematic review.

About one-third of individuals with diabetes develop diabetic retinopathy (DR), with one-tenth experiencing vision-threatening conditions such as diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Current treatments only show recovery in 50% of cases, and the disease often remains asymptomatic. Therefore, novel early detection methods and new biomarkers are crucial.

Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).

Natural killer group 2D (NKG2D) is a homodimeric activating immunoreceptor whose function is to detect and eliminate compromised cells upon binding to the NKG2D ligands (NKG2DL) major histocompatibility complex (MHC) molecules class I-related chain A (MICA) and B (MICB) and UL16 binding proteins (ULBP1-6). While typically present at low levels in healthy cells and tissue, NKG2DL expression can be induced by viral infection, cellular stress or transformation. Aberrant activity along the NKG2D/NKG2DL axis has been associated with autoimmune diseases due to the increased expression of NKG2D ligands in human disease tissue, making NKG2D inhibitors an attractive target for immunomodulation.

Mechanochromic Optical/Electrical Skin for Ultrasensitive Dual-Signal Sensing.

Following earlier research efforts dedicated to the realization of multifunctional sensing, recent developments of artificial skins endeavor to go beyond human sensory functions by integrating interactive visualization of strain and pressure stimuli. Inspired by the microcracked structure of spider slit organs and the mechanochromic mechanism of chameleons, this work aims to design a flexible optical/electrical skin (OE-skin) capable of responding to complex stimuli with interactive feedback of human-readable structural colors. The OE-skin consists of an ionic electrode combined with an elastomer dielectric layer, a chromotropic layer containing photonic crystals and a conductive carbon nanotube/MXene layer.