p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb.

Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK inhibitor p21 (CDKN1A), known to regulate the cell cycle and the viability of senescent cells, also controls the expression of extracellular matrix (ECM) components in senescent and proliferating cells of the fibrotic lung, in a manner dependent on CDK4 and Rb phosphorylation. p21 knockout protects mice from the induction of lung fibrosis.

A flexible employee recruitment and compensation model: A bi-level optimization approach.

The growing practice of flexible work following the COVID-19 pandemic is likely to have a significant impact on management and human resource (HR) practices. In this paper, we propose a novel bi-level mathematical programming model that can serve as a decision support tool for firms in real-life settings to improve recruitment and compensation decisions associated with hybrid and flexible work plans. The proposed model is composed of two levels: the first level reflects the company's goal of maximizing profitability by offering competitive salaries to candidates.

Smartphone use behavior and quality of life: What is the role of awareness?

How does smartphone use behavior affect quality of life factors? The following work suggests new insights into smartphone use behavior, mainly regarding two contradicting smartphone modes of use that affect quality of life in opposite ways. The Aware smartphone mode of use reflects an active lifestyle, while the Unaware mode of use reflects the use of the smartphone in conjunction with other activities. Using data from 215 individuals who reported their quality of life and smartphone use habits, we show that high levels of smartphone use in the Unaware mode of use have a significant negative effect on the quality of life.

The intricate nature of senescence in development and cell plasticity.

Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced secretory activity, has functional roles in both physiological and pathological conditions. Although senescence has been linked for a long time with cancer and ageing, recent studies have revealed a functional role of senescence in development, regeneration and reprogramming. Notably, the transient presence of senescent cells may be beneficial, in contrast to the potential deleterious effects of persistent senescence in aged or chronically damaged tissues.