Publications by authors named "H V Manjunathachar"
Introduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.
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- * Traditional diagnostic methods for cysticercosis lack sensitivity and require specialized labs, making effective disease control challenging.
- * A new recombinant Ag2-based dot blot assay was developed, showing high sensitivity (89%) and specificity (100%), indicating it could be a cost-effective and reliable diagnostic tool for use in low-resource settings.
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- * A systematic review and meta-analysis of 60 studies indicated a seroprevalence rate of 26.41% for scrub typhus among acute febrile cases in India, highlighting its prevalence as a public health issue.
- * The study also found a case fatality rate of 7.69% among those diagnosed with scrub typhus, emphasizing the need for prioritized preventive measures against this disease.
Leptospirosis, an underdiagnosed zoonotic disease in India, was studied retrospectively in Madhya Pradesh, Central India. Between 2018 and 2019, 2617 samples from patients with hepatitis-related symptoms were collected. Of these, 518 tested negative for hepatitis and other tropical viral diseases under the VRDL project were analyzed for leptospira IgM using ELISA.
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- - The text discusses the significant threat that genetic diversity in ticks poses to livestock health and agricultural economies globally, highlighting their adaptability to various environments and hosts.
- - It reviews three key genetic markers—COX1 gene, ribosomal genes, and microsatellites—used to study tick genetic diversity, emphasizing the strengths and limitations of each marker in species differentiation and population studies.
- - The implications of genetic diversity for vaccine development, particularly the Bm86 vaccine, and the understanding of synthetic pyrethroid resistance in ticks are also addressed, underscoring the need for tailored genetic approaches in tick management strategies.