Publications by authors named "H V Giles"

Intergenerational communication and aging is a thriving interdisciplinary, methodologically diverse field having significant implications for understanding the aging process. This opening article to the special issue provides a brief overview of this research domain, with particular attention to theoretical practices within it. Communication accommodation theory (CAT) is introduced given it has provided a foundation for other well-cited models of communication and aging.

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Background & Aims: Therapeutic plasma exchange (PEX) has emerged as a potential treatment option for patients with acute liver failure (ALF). The effect of PEX on survival outcomes outside of clinical trials is not yet well established. In this study we aimed to evaluate the real-world use and outcomes of PEX for the treatment of ALF.

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This study investigated cardiorespiratory fitness (CRF) levels and the relationship with field-based measures of anthropometry in children aged 10 to 11 years. . A total of 288 boys and 257 girls participated in the study.

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Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have focused on the prefrontal cortex. Analyzing BrainSeq Consortium data (caudate nucleus: n = 399, dorsolateral prefrontal cortex: n = 377, and hippocampus: n = 394), we identified 831 unique genes that exhibit sex differences across brain regions, enriched for immune-related pathways.

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Article Synopsis
  • Tissue gene expression studies can be significantly influenced by both biological and technical variation, categorized into wanted and unwanted types, where unmanaged unwanted variation could lead to erroneous conclusions.
  • In a large investigation using 17,282 samples from 49 human tissues, researchers analyzed gene expression patterns to identify and categorize 522 variable transcript clusters based on their causes, with a notable portion being linked to specific biological or technical factors.
  • The study revealed common variables such as sex, sequencing contamination, and tissue composition affecting gene expression, while also confirming that many identified causes of bulk tissue variation align with single-cell expression data from the Tabula Sapiens dataset, emphasizing the importance of combined methodologies.
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