α-Amylase inhibitory potential of dihydropyrano coumarins: In silico and DFT analysis.

Unlabelled: Coumarin derivatives are one of the naturally occurring bioactive molecule. Dihydropyrano coumarins are one of the medicinally important derivatives of coumarin which have been reported to exhibit various bioactivity. However, there are no reports on their antihyperglycemic activities.

Unveiling the Dissociation Mechanism of Diglycine Perchlorate.

Determining the dissociation mechanism of perchlorate materials remains a top priority to address sustainability, handling, processing, and synthesis issues of new and existing high-energy density materials vital to many industrial processes. We determined the dissociation mechanism of diglycine perchlorate (DGPCl) using vibrational spectroscopy, which unveiled the formation of ammonium perchlorate (AP) and carbon at high temperatures. Our studies establish that DGPCl shows multiple phase transitions upon heating.

Management of Recurrent Vancomycin-resistant Bacteremia With Oritavancin: A Case Report.

Background/aim: Vancomycin-resistant Enterococcus causes significant morbidity, mortality, and excess healthcare costs when compared to vancomycin-susceptible isolates. Patients with hematological malignancies, especially those who undergo hematopoietic stem cell transplantation, are at a particularly high risk for infections with vancomycin-resistant Enterococcus, with mortality ranging from 40-100%. Linezolid and daptomycin are the two most commonly used antibiotics for treatment of vancomycin-resistant enterococcal infections, however, there has been recent emergence of resistance to these drugs as well.

Silver-Catalyzed Synthesis of 5-Amino-4-sulfonyl Pyrazoles from 1,2-Diaza-1,3-dienes.

A facile and dependable synthetic route for 5-amino-4-sulfonyl pyrazoles, which are substantially important in pharmaceuticals, is highly desirable. This work presents a novel cascade reaction for their efficient synthesis. The approach utilizes silver as a catalyst for C(sp)-H sulfonylation of readily available starting materials 1,2-diaza-1,3-dienes with sulfinate salts, followed by intramolecular cascade cyclization annulation to afford the desired 5-amino-4-sulfonyl pyrazoles in good to excellent yields under mild conditions.