Publications by authors named "H Umit Ulas"
Background: The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms.
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- The study explored the link between the exposome score for schizophrenia (ES-SCZ), which represents cumulative environmental exposures, and cognitive impairments in individuals with schizophrenia spectrum disorders (SSD), their unaffected siblings, and healthy controls.
- Using assessments like the WAIS-III, DFAR, and BFR, researchers analyzed a sample of 1200 patients, 1371 siblings, and 1564 healthy subjects to evaluate cognitive performance across different domains.
- The findings showed no significant relationship between ES-SCZ and cognitive abilities in SSD patients; however, siblings and healthy controls exhibited a negative correlation with cognitive scores, indicating that environmental factors may impact those without the disorder differently.
Schizophrenia is frequently accompanied with social cognitive disturbances. Cannabis represents one established environmental factor associated with the onset and progression of schizophrenia. The present cross-sectional study aimed to investigate the association of facial emotion recognition (FER) performance with cannabis use in 2039 patients with schizophrenia, 2141 siblings, and 2049 healthy controls (HC).
View Article and Find Full Text PDFExamining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study.
Prog Neuropsychopharmacol Biol Psychiatry
March 2022
Background: Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ).
Methods: The sample comprised 2039 individuals with schizophrenia, 2141 siblings, and 2049 healthy controls (HC).
Background: A cumulative environmental exposure score for schizophrenia (exposome score for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients with schizophrenia spectrum disorder, unaffected siblings, and healthy controls.
Methods: This cross-sectional sample consisted of 1,261 patients, 1,282 unaffected siblings, and 1,525 healthy controls.