Publications by authors named "H Umeno"
Elastic cartilage properties of the tip of the vocal process of the arytenoid cartilage.
Laryngoscope Investig Otolaryngol
February 2025
Objectives: This study aimed to investigate the histological and ultrastructural features of the elastic cartilage at the tip of the vocal process in the arytenoid cartilage, which is essential for laryngeal biomechanics.
Methods: Five larynges, including the vocal folds and epiglottis, were examined using transmission electron microscopy. The elastic cartilage at the tip of the vocal process was compared to the epiglottic cartilage within the same larynx to elucidate structural differences.
We aimed to establish a useful molecular marker for differentiating between follicular thyroid carcinoma (FTC) and follicular adenoma (FA). RNA was extracted from the invasive front and paired tumor center tissues from three FTC cases using laser microdissection for cDNA microarray analysis, revealing high expression of gamma-glutamyl cyclotransferase (GGCT) in the invasive front. Subsequently, immunohistochemical (IHC) staining of GGCT was performed with formalin-fixed paraffin-embedded (FFPE) sections of FTC (n = 32), FA (n = 64), and follicular tumor of uncertain malignant potential (FT-UMP, n = 5).
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- The study examines how the epiglottis and preepiglottic space (PES) have evolved in primates, particularly focusing on their roles in vocal function and swallowing.
- It compares the larynges of various nonhuman primates (lemurs, galagos, macaques, gorillas, and chimpanzees) with humans, using detailed anatomical techniques to analyze differences.
- The findings suggest that changes in the structure of the epiglottis and PES over evolution have allowed for a longer pharyngeal space, which enhances speech production in humans and improves swallowing mechanics.
Article Synopsis
- This study examined factors that predict how well head and neck cancer patients respond to nivolumab, an anti-PD-1 treatment, focusing on clinical, microenvironmental, and genomic aspects.
- It analyzed 100 patients, revealing that responders typically had lower smoking and drinking habits, more immune-related side effects, and higher PD-L1 expression compared to non-responders.
- Additionally, factors like age, previous treatment with cetuximab, and specific gene mutations affected the response to treatment, highlighting the complexity of immune responses in cancer therapy.
Background: Chemoradiation therapy with high-dose cisplatin is the standard regimen against advanced squamous cell carcinoma of the larynx (SCC-L). However, patients with renal dysfunction are ineligible for this regimen. We investigated the effectiveness and feasibility of selective intra-arterial low-dose cisplatin infusion and radiotherapy (modified [m]-RADPLAT) for patients with impaired renal function.
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