Publications by authors named "H U Pesch"
Article Synopsis
- A new light-driven catalytic process is introduced for creating 3-pyrrolines using a combination of disulfide assistance and selenium catalysts, achieving yields up to 95%.
- The method effectively converts a variety of sulfonamides with diverse olefinic structures while maintaining good tolerance for functional groups.
- Mechanistic studies reveal that the disulfide co-catalyst plays a dual role: it acts as an electron shuttle and enhances the final product release step, leading to better yields.
We report a new class of stable mesoionic N-heterocyclic olefins, featuring a highly polarized (strongly ylidic) double bond. The ground-state structure cannot be described through an uncharged mesomeric Lewis-structure, thereby structurally distinguishing them from traditional N-heterocyclic olefins (NHOs). mNHOs can easily be obtained through deprotonation of the corresponding methylated N,N'-diaryl-1,2,3-triazolium and N,N'-diaryl-imidazolium salts, respectively.
View Article and Find Full Text PDFA synthetic method has been developed for the preparation of dihalo(pyridinium)sulfuranes and their transformation into alkynylthiopyridinium salts, starting from inexpensive thiopyridones. The reactivity of these salts towards different nucleophiles is evaluated. Most thiols and amines are converted into dithioesters and thioamides, respectively; whereas sterically demanding thiols delivered alkynylthioethers.
View Article and Find Full Text PDFStudy Objectives: To evaluate adherence to sodium oxybate prescribing information for indication and dosage, patients' compliance with instructions for use, safety/tolerability in routine clinical practice, and abuse potential.
Methods: A postauthorization, noninterventional surveillance study (NCT00244465) in patients who were prescribed sodium oxybate according to current practice by sleep disorders specialists. Patients were monitored for ≤18 months.
Objective: In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson's disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulations of rotigotine (improved room temperature-stable [PR2.3.
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