Wear pattern-associated color stability of prefabricated composite veneers versus ceramic veneers.

Purpose: To evaluate the effect of different surface wear patterns on the discoloration tendency of two different prefabricated composite veneers and lithium disilicate ceramic veneers.

Materials And Methods: Discoloration tendency of two prefabricated composite resin veneers (Visalys Veneer Chairside (VIS) and Componeer (COM)) were compared to lithium disilicate veneers (IPS) in vitro. For each material, n = 60 samples were allocated to different test groups, and therefore each n = 10 specimens per group went through different wear tests.

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.

Novel therapies for the treatment of acute myeloid leukemia (AML) are urgently needed, because current treatments do not cure most patients with AML. We report a domain-focused, kinome-wide CRISPR-Cas9 screening that identified protein kinase targets for the treatment of AML, which led to the identification of Rio-kinase 2 (RIOK2) as a potential novel target. Loss of RIOK2 led to a decrease in protein synthesis and to ribosomal instability followed by apoptosis in leukemic cells, but not in fibroblasts.

Comparison of Wear Resistance of Prefabricated Composite Veneers Versus Ceramic and Enamel.

Purpose: To measure surface roughness before and after wear-tests of two different prefabricated composite veneers and compare them to ceramic veneers and human dental enamel.

Materials And Methods: Roughness (Ra-values) of two prefabricated composite veneers (Visalys Veneer Chairside (VIS) and Componeer (COM)) were compared to lithium disilicate Veneers (e.max CAD) and dental enamel (DENT) in vitro.

variants in cause sporadic early-onset progressive sensorimotor neuropathy.

Background: Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system. Biallelic variants in have been associated with autosomal-recessive hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC). We identified heterozygous de novo variants in in three unrelated patients with intermediate CMT.

Comparison of Gingival Retraction Materials Using a New Gingival Sulcus Model.

Purpose: To investigate the pressure generated by different retraction materials using a novel gingival sulcus model.

Materials And Methods: A gingival sulcus model was made using a polymer frame filled with silicon. A pressure sensor and a sulcus-fluid simulation were embedded into the silicon chamber to evaluate the pressure generated by different retraction materials.