Publications by authors named "H U De Schepper"
Article Synopsis
- A 59-year-old patient with a history of peripheral T-cell lymphoma (PTCL-NOS) developed severe diarrhea three months post-treatment.
- After thorough investigation, it was discovered that the lymphoma had recurred specifically in the gastrointestinal tract.
- This case is notable as it represents a rare occurrence of predominant gastrointestinal recurrence of PTCL-NOS, with no previous reports documented in literature.
Article Synopsis
- Acute and chronic anal fissures are common health issues that lead to significant discomfort and frequent doctor visits; therefore, evidence-based treatment guidelines are crucial.
- A Delphi consensus method was used to review existing literature and create a set of statements regarding the treatment options for anal fissures, finalized by January 2023.
- The guidelines emphasize that both men and women are equally affected, conservative treatments should be tried first, and surgical options like lateral internal sphincterotomy and fissurectomy can be considered if conservative methods fail.
Efficacy of mast cell directed therapies in irritable bowel syndrome: a systematic review.
Acta Gastroenterol Belg
March 2024
Background And Study Aim: Lately, mast cells (MCs) are increasingly implicated in the pathophysiology of irritable bowel syndrome (IBS). The aim of this systematic review was to assess the efficacy of mast cell directed therapies in reducing the main symptoms of IBS: abdominal pain and changes in stool frequency or consistency.
Patients And Methods: Pubmed, Web of Science and Scopus were searched until December 19, 2022.
Objective: We evaluated the histamine 1 receptor antagonist ebastine as a potential treatment for patients with non-constipated irritable bowel syndrome (IBS) in a randomised, placebo-controlled phase 2 study.
Methods: Non-constipated patients with IBS fulfilling the Rome III criteria were randomly assigned to 20 mg ebastine or placebo for 12 weeks. Subjects scored global relief of symptoms (GRS) and abdominal pain intensity (API).