Head-to-head comparison of relative cerebral blood flow derived from dynamic [F]florbetapir and [F]flortaucipir PET in subjects with subjective cognitive decline.

Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R obtained from different PET tracers still require validation.

Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study.

Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact strongly (functional connectivity); through the pattern of anatomical connections (structural connectivity); or simple diffusion. Using magnetoencephalography (MEG), we investigated which spreading pathways influence tau protein spreading by modelling the tau propagation process using an epidemic spreading model.

Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study.

Purpose: Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer's disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurrent and longitudinal tau PET with longitudinal changes in atrophy and relative CBF.

Methods: We included 61 individuals from the Amsterdam Dementia Cohort (mean age 65.

Longitudinal Tau PET Using F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters.

Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BP) are not. For F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown.

A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum.

Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer's disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. We included participants from the Amsterdam Dementia Cohort who underwent F-flortaucipir (tau) PET and had a plasma sample biobanked within 12 mo from tau PET.