Publications by authors named "H Tsukui"
Unlabelled: Septal reduction therapy is an effective treatment for hypertrophic obstructive cardiomyopathy (HOCM). Alcohol septal ablation (ASA) is indicated for HOCM patients who are ineligible for surgical myectomy, but several tips exist for the management of high-risk patients with ASA. Here, we present a case of successful ASA in a HOCM patient with multiple comorbidities, including severe obesity, drug-refractory bronchial asthma, poorly controlled diabetes, and steroid-induced immunosuppression.
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- Endotoxemia is a serious inflammatory condition triggered by lipopolysaccharide (LPS), leading to the release of inflammatory cytokines, which can be partly managed by fuzapladib (FZP) that inhibits inflammation.
- In a study with 15 pigs divided into low-FZP, high-FZP, and control groups, researchers assessed how FZP affected inflammation and cardiac function after inducing endotoxemia with LPS.
- Results showed that while high-FZP didn't prevent organ damage, it reduced interleukin-6 levels and helped maintain better blood oxygen levels and blood pressure than the control, ultimately reducing mortality during the observation period.
Key Clinical Message: Disseminated carcinomatosis of the bone marrow is rare. We present such a case, which is useful for raising awareness about the importance of early diagnosis and treatment of carcinomas complicated by disseminated carcinomatosis of the bone marrow.
Abstract: This is the first autopsy report of disseminated carcinomatosis of the bone marrow (DCBM) in esophageal adenocarcinoma.
Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subcutaneously (sc) in BALB/c mice and treated with metformin and/or local radiation (RT).
View Article and Find Full Text PDFAim: The clinical efficacy of chemoradiotherapy (CRT) is largely dependent on host immune status. The aim of this study was to identify possible markers expressed on circulating mononuclear cells to predict tumour response in patients with locally advanced rectal cancer (LARC).
Methods: Peripheral blood samples were obtained from 47 patients diagnosed with LARC before and after CRT.