Publications by authors named "H Treiber"

The acquisition of subsequent genetic lesions (clonal evolution, CE) and/or the expansion of existing clones (CEXP) contributes to clonal dynamics (CD) in myelodysplastic syndromes (MDS). Although CD plays an important role in high-risk patients in disease progression and transformation into acute myeloid leukemia (AML), knowledge about CD in lower-risk MDS (LR-MDS) patients is limited due to lack of robust longitudinal data considering the long clinically stable courses of the disease. In this retrospective analysis, we delineate the frequency and the prognostic impact of CD in an unselected real-world cohort of LR-MDS patients.

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  • Systemic sclerosis (SSc) is a serious autoimmune disease with limited treatment options, and high-dose chemotherapy combined with autologous stem cell transplantation (HD-ASCT) has shown effectiveness, though it comes with substantial risks.
  • A study analyzed 32 SSc patients who underwent HD-ASCT between 2000 and 2020, focusing on their survival rates, treatment-related mortality (TRM), and factors influencing outcomes.
  • The results indicated a median overall survival of 81 months, with 77% responding positively to treatment within a year, though TRM remains a significant issue, highlighting the importance of identifying high-risk patients and considering individual prognostic factors to potentially improve outcomes.
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  • Identifying the best treatment for elderly patients with localized non-small cell lung cancer (NSCLC) is difficult, but low-dose cisplatin chemotherapy is a potential option with less toxicity.
  • In a study comparing patients aged 70 and older to younger ones, elderly patients had more health issues and lower stages of cancer, but they experienced fewer severe side effects with low-dose cisplatin compared to cisplatin/vinorelbine.
  • To improve survival outcomes for elderly patients, multimodal treatment strategies, including surgery and systemic therapy, should be considered, and the use of low-dose cisplatin should be tailored to each patient due to its acceptable toxicity profile.
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The internal organ at risk volume (IRV) concept might improve toxicity profiles in stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). We studied (1) clinical aspects in central vs. peripheral tumors, (2) the IRV concept in central tumors, (3) organ motion, and (4) associated normal tissue complication probabilities (NTCPs).

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