Publications by authors named "H Toussaint"
Background: A consistent finding in the literature is the decline in physical activity during adolescence, resulting in activity levels below the recommended guidelines. Therefore, promotion of physical activity is recommended specifically for prevocational students.
Objective: This protocol paper describes the background and design of a physical activity promotion intervention study in which prevocational students are invited to participate in the design and implementation of an intervention mix.
Background: Approximately 5%-10% of elementary school children show delayed development of fine motor skills. To address these problems, detection is required. Current assessment tools are time-consuming, require a trained supervisor, and are not motivating for children.
View Article and Find Full Text PDFA Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
Br J Cancer
November 2020
Article Synopsis
- AsiDNA is an innovative therapy that mimics double-stranded DNA breaks to trigger a response in tumor cells, engaging key enzymes that play a role in DNA repair.
- A Phase 1 study was conducted with 22 patients having advanced solid tumors to evaluate the drug's safety, tolerability, and pharmacokinetics, using various dose levels.
- The maximum tolerated dose was never reached, but the 600 mg dose was determined to be optimal for future studies, with a few cases of serious side effects reported at higher doses.
Aim: To assess the concurrent validity and discriminative ability of total, gross and fine motor (TM, GM and FM) scores of Dutch performance-based motor tests, the Baecke-Fassaert Motor Test (BFMT) and the 8- and 4-Skills Scan (SkSc) with the Movement Assessment Battery (MABC) for children at age 5.
Method: 116 Dutch children (40.3% boys) were included.
Purpose: Literature detailing the effectiveness of school-based physical activity promotion interventions in prevocational adolescents was reviewed to identify effective intervention characteristics.
Methods: The search strategy assessed studies against inclusion criteria study design, study population, school setting, language, and construct. The risk of bias of the included studies was assessed, and extractions were made of the physical activity (PA) level outcome measures and intervention characteristics regarding organizational, social, and content features.