Publications by authors named "H Topal"
Background: Pancreatic neuroendocrine tumors (pNETs) are rare tumors with heterogeneous outcomes. The aim of our study was to determine the long-term outcome, recurrence patterns, as well as the clinical and pathological factors that impact time-to-recurrence (TTR), recurrence-free survival (RFS), and overall survival (OS) in pNETs treated with curative surgery.
Methods: Data for all patients who underwent radical surgery with curative intent for non-metastatic pNETs were obtained from a prospectively maintained database of the University Hospitals Leuven.
Genetic Variations and Serum Levels of Leptin and Ghrelin in Autism Spectrum Disorder.
Psychiatry Clin Psychopharmacol
September 2024
Background: This study aims to examine leptin and ghrelin gene polymorphisms and serum levels in children with autism spectrum disorder (ASD).
Methods: The study comprised a case group of 40 children aged 2-7 diagnosed with ASD and a control group of 40 healthy children. The severity of ASD symptoms was assessed using the Childhood Autism Rating Scale and the Autism Behavior Checklist.
Signet ring cells in the gastrointestinal tract: not always what it seems.
Acta Gastroenterol Belg
October 2024
Article Synopsis
- - Two cases of pseudo-signet ring cells in gastric biopsies were found in otherwise healthy adult males, highlighting a rare nonmalignant condition that can mimic cancer.
- One patient, previously treated for intestinal type gastric adenocarcinoma, underwent surgery before the condition was identified, leading to complications, while the second patient avoided surgery due to early recognition.
- The text emphasizes the importance of careful examination by experienced professionals to prevent misdiagnosis and unnecessary medical procedures when no endoscopic abnormalities are present.
Article Synopsis
- A case series highlights positive results for patients with gastrointestinal (GI) cancer characterized by deficient mismatch repair (dMMR) who underwent surgery to remove a single worsening tumor while undergoing immunotherapy.
- The study shows that this combined approach of surgery and immunotherapy can lead to excellent patient outcomes.
- These findings suggest that carefully selected patients with dMMR GI cancer may benefit significantly from this treatment strategy.
A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors of patients with pancreatic ductal adenocarcinoma (PDAC) and explore how this could affect therapy response. By mimicking this observation in PDAC cell lines, we demonstrate that through adaptive changes in lipid metabolism, the temperature increase found in human PDAC confers protection to lipid peroxidation and contributes to gemcitabine resistance.
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