Publications by authors named "H Tomihara"
The therapeutic benefit of recently developed mutant KRAS (mKRAS) inhibitors has been limited by the rapid onset of resistance. Here, we aimed to delineate the mechanisms underlying acquired resistance to mKRAS inhibition and identify actionable targets for overcoming this clinical challenge. Previously, we identified Syndecan-1 (SDC1) as a key effector for pancreatic cancer progression whose surface expression is driven by mKRAS.
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- Robotic distal gastrectomy (RDG) with Billroth I (BI) reconstruction is enhanced by the Intracorporeal Triangular Anastomotic Technique (INTACT), which aims to minimize ischemic areas and improve surgical consistency and safety.
- The surgical process involves precise dissection and anastomosis techniques using robotic arms to ensure a stable and effective reconstruction.
- In a study of 81 patients, the procedure showed promising results with no significant complications, including no blood loss and a median hospital stay of 8 days, highlighting the technique's effectiveness and reliability.
Article Synopsis
- As gastric cancer rates rise among older populations, the CPAS program aims to improve surgical outcomes for elderly patients through comprehensive preoperative assessments, focusing on frailty and sarcopenia.
- In a study of 127 elderly patients who underwent surgery with CPAS, results showed less blood loss, fewer serious complications, and shorter hospital stays compared to a historical control group, particularly highlighting the benefits in managing infections and respiratory issues.
- The findings indicate that personalized preoperative care through CPAS significantly increases surgical safety and lowers complication rates for elderly gastric cancer patients, suggesting a need for broader implementation.
Background: Occupational cholangiocarcinoma is associated with exposure to organic solvents, such as dichloromethane (DCM) and 1,2-dichloropropane (DCP). This report describes a case of occupational cholangiocarcinoma detected through regularly imaging following the discovery of elevated serum γ-glutamyl trans peptidase (γ-GTP) levels revealed during regular checkup.
Case Presentation: A 43-year-old man who had been working in a printing company with 15 years of exposure to organic solvents presented to our hospital owing to abnormalities found during a routine checkup.
Background: The increasing incidence of gastric cancer in the elderly underscores the need for an in-depth understanding of the challenges and risks associated with surgical interventions in this demographic. This study aims to investigate the risk factors and prognostic indicators for non-cancer-related mortality following curative surgery in elderly gastric cancer patients.
Methods: This retrospective analysis examined 684 patients with pathological Stage I-III gastric cancer who underwent curative resection between January 2012 and December 2021.