Harnessing electromagnetic data for tsunami source estimation: a comprehensive review.

Ocean-bottom pressure gauges are widely used for tsunami observations due to their established accuracy and stability. Recent advancements reveal that the magnetic field fluctuates when a large tsunami passes over the ocean, suggesting potential alternatives to pressure gauges in the form of ocean-bottom electromagnetometers (OBEMs). This article offers a comprehensive synthesis of recent findings concerning tsunami magnetic fields and their utility in tsunami source estimation.

Impact of Antibiotics and Chronic Medications on Efficacy of Immune Checkpoint Inhibitors in Patients With Hepatocellular Carcinoma.

Background And Aims: The interaction of immune checkpoint inhibitors (ICI) and concomitant medications such as antibiotics, metformin, statins, beta-blockers, proton pump inhibitors (PPIs), nonsteroidal anti-inflammatory drugs (NSAIDs), and low-dose aspirin has been studied in other malignancies. Our study aims to investigate the relationship between these medications and ICI efficacy in patients with advanced hepatocellular carcinoma (aHCC).

Methods: A retrospective review of patients who received at least one dose of ICIs between May 2015 and November 2019 was performed.

Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells.

Background: The placenta is essential for nutrient exchange and hormone production between the mother and the developing fetus and serves as an invaluable model for epigenetic research. Most epigenetic studies of the human placenta have used whole placentas from term pregnancies and have identified the presence of partially methylated domains (PMDs). However, the origin of these domains, which are typically absent in most somatic cells, remains unclear in the placental context.