Malignant Phyllodes Tumor in a Pubertal Girl: A Report of a Case.

Background: Malignant phyllodes tumor (MPT) is a rare breast disease that is extremely rare in children. A few cases of pediatric malignant phyllodes tumors have been reported, including some with a poor prognosis.

Case: A 14-year-old girl presented with a growing lump on her right breast.

[The Hope for a Gastric Cancer Treatment Guideline for Patients-The Future through the Guideline].

When my husband was diagnosed as stage 4 gastric cancer, I sincerely wanted to help him. I believed that somewhere in the world there must be a doctor who could cure him. Unfortunately, I did not know how to choose the right information.

A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.

Multiple genetic factors related to autism spectrum disorder (ASD) have been identified, but the biological mechanisms remain obscure. Timothy syndrome (TS), associated with syndromic ASD, is caused by a gain-of-function mutation, G406R, in the pore-forming subunit of L-type Ca channels, Ca 1.2.

Total Synthesis of Talatisamine.

Talatisamine (1) is a member of the C -diterpenoid alkaloid family, and exhibits K channel inhibitory and antiarrhythmic activities. The formidable synthetic challenge that 1 presents is due to its highly oxidized and intricately fused hexacyclic 6/7/5/6/6/5-membered-ring structure (ABCDEF-ring) with 12 contiguous stereocenters. Here we report an efficient synthetic route to 1 by the assembly of two structurally simple fragments, chiral 6/6-membered AE-ring 7 and aromatic 6-membered D-ring 6.